Wednesday, 22 March 2017

@Phil Fantastic Voyage | Script Ending Ideas

You mentioned that there ought to be a Scene 5 in my script, but I'm not too sure how it should end.

- I could change the entire ending to the patient receiving chemotherapy and having a new liquid colour (possibly yellow as that is the colour of methotrexate) flushing out and/or destroying the roaming cancer cells and keeping the tumours at bay

- The ending could stay the same as it is but either the narrator or on-screen text issues a kind of warning that cancer can strike at any age (or something to that effect), kind of like an advert

At the moment I prefer the idea of the advert, but if you can think of a better way to end it, please let me know

Friday, 10 March 2017

Fantastic Voyage | 2nd Cancer Cell Influence Map

Fantastic Voyage | Research - How a Healthy Cell Becomes Cancerous

How do cells become cancerous?

"The DNA found in every cell in the body is responsible for governing all the actions the cell takes, according to the American Cancer Society. In a normal cell, whenever its DNA becomes damaged, it either repairs the damage or simply dies. In cancer cells, this behavior is different. Instead of repairing the damage or dying, the cell continues to make new abnormal cells the body doesn't need. As a result, these new cells have the same damaged DNA as the first and subsequently continue to divide and grow, eventually forming an abnormal collection of cells called a tumor. Over time, these tumors can crowd out, invade or push surrounding healthy tissue aside, causing damage to the body or organ.

Some people inherit the defect in a cell's DNA, states the American Cancer Society. However, most defects in a cell's DNA happen either when the cell divides or as a result of environmental factors, such as smoking or too much exposure to the sun. However, it is often rare to know what caused a cell's DNA to become damaged in the first place."

Fantastic Voyage | Research - How Cancer Spreads

Cancer can spread in 3 ways:
  • invasion (direct extension) – The tumour grows into surrounding tissues or structures.
  • through the bloodstream (hematogenous spread) – Cancer cells break away from the tumour, enter the bloodstream and travel to a new location in the body.
  • through the lymphatic system – Cancer cells break away from the tumour and travel through the lymph vessels and lymph nodes to other parts of the body.

"Cancer cells can be carried in the bloodstream or lymphatic system to other parts of the body. There they can start to grow into new tumours."

"In order to spread, some cells from the primary cancer must break away, travel to another part of the body and start growing there. Cancer cells don't stick together as well as normal cells do. They may also produce substances that stimulate them to move. "

a malignant tumour

"The circulating blood sweeps the cancer cells along until they get stuck somewhere. Usually they get stuck in a very small blood vessel called a capillary."

"Then the cell must move through the wall of the capillary and into the tissue of the organ close by. The cell can multiply to form a new tumour if the conditions are right for it to grow and it has the nutrients that it needs."

a cancer cell stuck in a small blood vessel capillary

how cancer cells get into the bloodstream

Fantastic Voyage | More Influences

Pacific Light from Ruslan Khasanov on Vimeo.

I think both of these would work well as a representation of cancer, but I will be taking more from 'Pacific Light'. The opening scene with the ink bubbles moving suddenly towards the camera would work really well as a shot of cells flowing through the body, while the shots of many smaller bubbles from further away can be used to show the mass of cells.

I think it would be interested to show the 'normal' cells as spheres, like the ink droplets, but have cancer represented by the large amounts of flowing ink.

I still need to think more about how I can present a cell becoming cancerous so I'll be doing plenty of research on that but I have some ideas about how to show the spread of cancer and the representation of healthy cells.

Wednesday, 8 March 2017

@Phil - Fantastic Voyage | Idea

Earlier, Jordan showed me some screenshots of 'Dots' by Norman McLaren. I like the look of the dots and the different shapes they form as well as the vivid colours that he used. As an introduction to the cells, I could use shapes like these:

But, to show the process of a cell becoming cancerous and the spread of cancer through the body, I could adapt/transfer them to something more similar to this:

I could use this kind of animation to show the cancer flooding through the body of the victim; destroying and multiplying as it goes, while appealing to an older, more mature audience. I could also focus specifically on prostate cancer or breast cancer to inform young people to be aware and let them know that you can get it while young and, while rare, is typically more aggressive in young people.

Would it be possible to create something like this in Maya?

Fantastic Voyage | Cancer Cell Research

"A healthy cell does not turn into a cancer cell overnight. Its behaviour gradually changes, a result of damage to between three and seven of the hundreds of genes that control cell growth, division and life span. First, the cell starts to grow and multiply. Over time, more changes may take place. The cell and its descendants may eventually become immortal, escape destruction by the body's defences, develop their own blood supply and invade the rest of body."

"A cell is continuously receiving messages, both from its own genes and from other cells. Some tell it to grow and multiply, others tell it to stop growing and rest, or even to die. If there are enough 'grow' messages, the next stage of the cell's life starts. In a cancer cell, the messages to grow may be altered, or the messages to stop growing or to die may be missing. The cell then begins to grow uncontrollably and divide too often."

"Every time a normal cell divides, the ends of its chromosomes become shorter. Once they have worn down, the cell dies and is replaced. Cancer cells cheat this system - they retain their long chromosomes by continually adding bits back on. This process allows cancer cells to live forever. Cells from Henrietta Lacks, an American woman who was diagnosed with cervical cancer in 1951, are still growing. They are used in research laboratories all over the world, many years following her death."

"Every time a healthy human cell divides, it copies all its genes, which are bundled up into 46 chromosomes. This process has several checkpoints to ensure that each new cell gets a near-perfect copy. But in a cancer cell, these checkpoints are often missing. The result is chaos: parts of chromosomes may be lost, rearranged or copied many times and the genes are more likely to acquire further mutations. Some of these may allow the cell to escape other checking and repair mechanisms."

"All the cells in your body usually work together as a community. But if a cell acquires a gene mutation that makes it multiply when it should not, or helps it survive when other cells die, it has an advantage over the others. Eventually, the abnormal cells acquire mutations in more genes, causing uncontrolled growth. These abnormal cells have a competitive advantage over normal cells. This is like natural selection in evolution, where a species that produces more offspring has a better chance of survival."

"In normal cells, gene damage is usually quickly repaired. If the damage is too severe, the cell is forced to die. An important protein called p53 checks for gene damage in normal cells, and kills them if the damage is too great to repair. However, in cancer cells these checking mechanisms are defective. Cancer cells often have an altered p53 protein, which does not work properly, allowing cancer cells to survive, despite their dangerously garbled genetic material."

"Any cells that start to multiply too much or in the wrong place are either stopped from growing, or forced into suicide by the process of apoptosis. In cancer cells, these instructions are either missing, altered or ignored. So cancer cells escape destruction, and continue to multiply in an uncontrolled way."

Fantastic Voyage | Influences

Fantastic Voyage | Cancer Cell Influence Map

Fantastic Voyage | Word List

  • Growth
  • DNA Replication
  • Division
  • Error
  • Mitosis
  • Cancer
  • G1
  • G2
  • Synthesis
  • Cell
  • Sectors
  • Pipeline
  • Security
  • Fault
  • Control
  • Destroy
  • Checkpoints
  • Suicide
  • Scan
  • Human Body
  • Blood
  • Veins
  • Flood
  • Invasion
  • Take-Over
  • Kill
  • Death

Sunday, 5 March 2017

From Script to Screen | Logline

During a play, a young Private Detective notices an understudy wearing the necklace belonging to a famous actress. Suspecting the worst, he goes in search of the actress, where he makes a gruesome discovery.

From Script to Screen | Premise

A young Private Detective must unravel the mystery surrounding an actress' disappearance.